Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer
Xiaoyi Li, Dingfeng Wu, Qiuyu Li, Jinglan Gu, Wenxing Gao, Xinyue Zhu, Wenjing Yin, Ruixin Zhu, Lixin Zhu, Na Jiao
Abstract
This study determined the following: 1) providing a comprehensive landscape of consensus molecular subtype (CMS)-specific tumor microenvironments (TMEs); 2) constructing CMS-specific networks, including host genes, intratumoral microbiota, and enriched pathways, analyzing their associations to uncover unique patterns that demonstrate the intricate interplay within the TME; and 3) revealing a connection between immune-rich subtypes and ferroptosis activation, suggesting a potential regulatory role of the microbiota in ferroptosis dysregulation of the colorectal cancer TME.
Topics & Concepts
BiologyTumor microenvironmentColorectal cancerCancerHost (biology)Cancer researchGeneticsColorectal Cancer Treatments and StudiesGut microbiota and healthCancer Immunotherapy and Biomarkers