Cisplatin−cyclooxygenase inhibitor conjugates, free and immobilised in mesoporous silica SBA-15, prove highly potent against triple-negative MDA-MB-468 breast cancer cell line
Ivana Predarska, Mohamad Saoud, Ibrahim Morgan, Thomas Eichhorn, Goran N. Kaluđerović, Evamarie Hey‐Hawkins
Abstract
values up to 240-fold lower than cisplatin. Flow cytometry assays clearly show that all compounds induce apoptotic cell death elevating the levels of both early and late apoptotic cells. Furthermore, autophagy as well as formation of reactive oxygen species (ROS) and nitric oxide (NO) were elevated to a similar or greater extent than with cisplatin.
Topics & Concepts
CisplatinChemistryMesoporous silicaCytotoxicityApoptosisConjugateTriple-negative breast cancerCell cultureCancer cellIC50PharmacologyStereochemistryBiophysicsBiochemistryIn vitroMesoporous materialCancerBreast cancerChemotherapyBiologyMathematical analysisMathematicsCatalysisGeneticsMetal complexes synthesis and propertiesNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers