Tuning the mechanistic pathways of peptide self-assembly by aromatic interactions
Goutam Ghosh, Kalathil K. Kartha, Gustavo Fernández
Abstract
Herein, we have unravelled the key influence of aromatic interactions on the mechanistic pathways of peptide self-assembly by introducing suitable chromophores (pyrene vs. naphthalene). Although both self-assembled peptides are indistinguishable in their morphologies, this minor structural difference strongly affects the packing modes (parallel vs. antiparallel) and the corresponding self-assembly mechanism (cooperative vs. isodemsic).
Topics & Concepts
PyreneNaphthaleneChromophorePeptideChemistrySelf-assemblyCombinatorial chemistryAromaticityOrganic chemistryBiochemistryMoleculeSupramolecular Self-Assembly in MaterialsPolydiacetylene-based materials and applicationsPhotochromic and Fluorescence Chemistry