HOTTIP downregulation reduces neuronal damage and microglial activation in Parkinson's disease cell and mouse models
Peng Sun, Peng Lun, Ji Tao, Dehong Wan, Xia Liu, Xiao-Dong Chen, Shuai Yu
Abstract
-induced neuronal apoptosis and microglial inflammation and ameliorated HOTTIP- and FOXO1-mediated nerve injury and inflammation. In vivo, HOTTIP knockdown alleviated motor dysfunction in PD mice and reduced neuronal apoptosis and microglial activation in the substantia nigra. These findings suggest that inhibition of HOTTIP mitigates neuronal apoptosis and microglial activation in PD models by modulating miR-615-3p/FOXO1. This study was approved by the Ethics Review Committee of the Affiliated Hospital of Qingdao University, China (approval No. UDX-2018-042) in June 2018.
Topics & Concepts
Gene knockdownSubstantia nigraMicrogliaApoptosisDownregulation and upregulationProinflammatory cytokineNeuroinflammationCancer researchInflammationGene silencingCell biologyChemistryMedicineBiologyParkinson's diseaseImmunologyInternal medicineDiseaseBiochemistryGeneCancer-related molecular mechanisms researchCircular RNAs in diseasesRNA regulation and disease