Dexmedetomidine alleviates pain in MPTP-treated mice by activating the AMPK/mTOR/NF-κB pathways in astrocytes
Yaohua Chen, Yuping Li, Chunxiang Li, Dan Zhu, Oumei Cheng, Jian Cui
Topics & Concepts
MPTPAMPKTyrosine hydroxylaseDopaminergicPharmacologyEndocrinologyPI3K/AKT/mTOR pathwayMedicineDopamineAstrocyteAllodyniaDeep brain stimulationChemistryInternal medicineHyperalgesiaNociceptionParkinson's diseaseCentral nervous systemProtein kinase APhosphorylationSignal transductionReceptorBiochemistryDiseaseParkinson's Disease Mechanisms and TreatmentsPain Mechanisms and TreatmentsNerve injury and regeneration