Recent advances in the development of β-lactamase inhibitors
Shivakumar S. Jalde, Hyun Kyung Choi
Abstract
β-Lactam antibiotics are the most commonly prescribed antibiotics worldwide; however, antimicrobial resistance (AMR) is a global challenge. The β-lactam resistance in Gram-negative bacteria is due to the production of β-lactamases, including extended-spectrum β-lactamases, metallo-β-lactamases, and carbapenem-hydrolyzing class D β-lactamases. To restore the efficacy of BLAs, the most successful strategy is to use them in combination with β-lactamase inhibitors (BLI). Here we review the medically relevant β-lactamase families and penicillins, diazabicyclooctanes, boronic acids, and novel chemical scaffold-based BLIs, in particular approved and under clinical development.
Topics & Concepts
AntibioticsMicrobiologyAntimicrobialAntibiotic resistanceBroad spectrumCarbapenemBeta-Lactamase InhibitorsBacteriaBiologyChemistryCombinatorial chemistryGeneticsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyAntibiotic Use and Resistance