Inhibiting Ferroptosis through Disrupting the NCOA4–FTH1 Interaction: A New Mechanism of Action
Yuying Fang, Xiu‐Cai Chen, Qingyun Tan, Huihao Zhou, Jun Xu, Qiong Gu
Abstract
is the first NCOA4-FTH1 interaction inhibitor. This work paves a new road to the development of ferroptosis inhibitors against neurological diseases.
Topics & Concepts
Programmed cell deathFerrousMechanism of actionGPX4ChemistryCell biologyOxidative stressBiologyBiochemistryApoptosisIn vitroSuperoxide dismutaseGlutathione peroxidaseOrganic chemistryFerroptosis and cancer prognosisDrug Transport and Resistance MechanismsCancer, Lipids, and Metabolism