A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic

Joseph R. Cohen, Stephen R. Brych, Siddharth Prabhu, Vivian Bi, Ahmed Elbaradei, Joshua M. Tokuda, Cathie Xiang, Martha Hokom, Xiaohong Cui, Chau Giang Ly, Nathan Amos, Jilin Sun, Dominador Calamba, Jonathan Herskovitz, Allyson Capili, Kimya Nourbakhsh, A. Merlo, Julia Carreon, Jette Wypych, Linda O. Narhi, Vibha Jawa, Marisa K. Joubert