Liposomal Delivery of MicroRNA-7 Targeting EGFR to Inhibit the Growth, Invasion, and Migration of Ovarian Cancer
Xiaojuan Cui, Keqi Song, Xiaolan Lu, Weiwei Feng, Wen Di
Abstract
-glycero-3-phosphoethanolamine, and cholesterol. The miR-7 liposomes had a suitable particle size, potential, and a high cellular uptake rate. MiR-7 encapsulated by liposomes could be effectively delivered to ovarian cancer cells and successfully targeted to the tumor site in a mouse xenograft model of ovarian cancer. In vitro and in vivo experiments revealed that the miR-7 liposomes had a significant ability to inhibit the growth, invasion, and migration of ovarian cancer, probably by inhibiting the expression of the epidermal growth factor receptor. Our studies of miR-7 liposomes demonstrated a safe and efficient microRNA delivery system for the gene therapy of ovarian cancer.
Topics & Concepts
Ovarian cancerCancer researchCationic liposomemicroRNALiposomeIn vivoGenetic enhancementMetastasisTransfectionGene deliveryCancerMedicineBiologyInternal medicineGeneBiochemistryBiotechnologyRNA Interference and Gene DeliveryMicroRNA in disease regulationAdvanced biosensing and bioanalysis techniques