SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
Oyahida Khatun, Mansi Sharma, Rohan Narayan, Shashank Tripathi
Topics & Concepts
IRF3InterferonUbiquitin ligaseBiologyUbiquitinInnate immune systemCell biologyRIG-ISignal transductionSTAT1Interferon type IVirologyViral replicationVirusImmune systemImmunologyBiochemistryGeneinterferon and immune responsesSARS-CoV-2 and COVID-19 ResearchPhagocytosis and Immune Regulation