Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer
Nguyễn Văn Nghĩa, Sang Jun Park, Sujie Qi, Jeongsun Ha, Seonye Heo, Yubin Yim, Gain Baek, Chang Su Lim, Dong Joon Lee, Hwan Myung Kim, Juyoung Yoon
Abstract
Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular, NIS-Me and CRNS display outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.
Topics & Concepts
Photodynamic therapyCancer therapyAtom (system on chip)ChemistryCancerPhotochemistryCombinatorial chemistryMedicineInternal medicineComputer scienceOrganic chemistryEmbedded systemNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials