Biocatalytic atroposelective synthesis of heterobiaryls and heterobiaryl <i>N</i>-oxides <i>via</i> dynamic kinetic resolution
Xinyue Hao, Bin Wang, Zhuangfei Tian, Zhouchang Yao, Tianzhang Qiao, Ling Huang, Haigen Fu
Abstract
A highly efficient biocatalytic dynamic kinetic resolution (DKR) for the asymmetric synthesis of axially chiral heterobiaryls and heterobiaryl N -oxides was developed using engineered imine-reductases (IREDs).
Topics & Concepts
ChemistryKinetic resolutionKinetic energyResolution (logic)Combinatorial chemistryOrganic chemistryCatalysisEnantioselective synthesisPhysicsArtificial intelligenceComputer scienceQuantum mechanicsAxial and Atropisomeric Chirality SynthesisChemical synthesis and alkaloidsMolecular spectroscopy and chirality