Selective<i>c-MYC</i>G4 DNA recognition based on a fluorescent light-up probe with disaggregation-induced emission characteristics
Hong‐Yao Li, Hao-Wen Cao, Xue‐Xian Lang, Yansong Chen, Ming‐Qi Wang
Abstract
triggered probe disaggregation and induced a significant increase in fluorescence intensity. The binding details discussed here suggest the basis for the recognition of a particular G4 structure, thus opening up a new way for the design and development of sequence-selective supramolecular G4 probes with desired properties.
Topics & Concepts
FluorescenceDNABODIPYSupramolecular chemistryTranscription (linguistics)Transcription factorPromoterChemistryBiophysicsComputational biologyBiologyGeneMolecular biologyCell biologyCombinatorial chemistryBiochemistryMoleculePhysicsGene expressionQuantum mechanicsOrganic chemistryLinguisticsPhilosophyAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryLuminescence and Fluorescent Materials