Multiple Origins of Extracellular DNA Traps
Edgar Ramos-Martínez, Leticia Hernandez‐Gonzalez, Iván Ramos-Martínez, Laura Pérez‐Campos Mayoral, Georgina I. López-Cortés, Eduardo Pérez‐Campos, Gabriel Mayoral Andrade, María Teresa Hernández‐Huerta, Marco V. José
Abstract
Extracellular DNA traps (ETs) are evolutionarily conserved antimicrobial mechanisms present in protozoa, plants, and animals. In this review, we compare their similarities in species of different taxa, and put forward the hypothesis that ETs have multiple origins. Our results are consistent with a process of evolutionary convergence in multicellular organisms through the application of a congruency test. Furthermore, we discuss why multicellularity is related to the presence of a mechanism initiating the formation of ETs.
Topics & Concepts
Multicellular organismEvolutionary biologyBiologyConvergent evolutionMechanism (biology)ProtozoaExtracellularNeutrophil extracellular trapsDNAGeneticsPhylogeneticsGeneImmunologyPhilosophyInflammationEpistemologyNeutrophil, Myeloperoxidase and Oxidative MechanismsAdvanced biosensing and bioanalysis techniquesAntibiotic Resistance in Bacteria