Isoquercitrin from <i>Apocynum venetum</i> L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione <i>S</i>-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice <i>in vivo</i>
Majid Manzoor, Makoto Muroi, Naoko Ogawa, Hiroki Kobayashi, Haruna Nishimura, Danni Chen, Opeyemi B. Fasina, Jianyu Wang, Hiroyuki Osada, Minoru Yoshida, Lan Xiang, Jianhua Qi
Abstract
-transferase P. These results suggested that isoquercitrin produces an anti-obesity effect by targeting the above-mentioned proteins and regulating the AMPK/SREBP-1c signaling pathway and potentially prevents obesity and obesity-related metabolic disorders.
Topics & Concepts
ChemistryATP synthasePharmacologyGlutathioneTransferaseReductaseEnzymeBiochemistryMedicineChromatography in Natural ProductsPharmacological Effects of Natural CompoundsGinseng Biological Effects and Applications