Triborane (B<sub>3</sub>H<sub>7</sub>)-mediated regioselective substitution reactions of pyridine derivatives
Zi‐Heng Fan, Jiaxin Kang, Sihan Jia, Qiao‐Jing Pan, Lei Cao, Ximeng Chen, Ximeng Chen, Cong‐Qiao Xu, Yan‐Na Ma, Xuenian Chen, Xuenian Chen
Abstract
pyridine derivatives are stable and do not dissociate or decompose during the reaction process. The high stability of the B-N bond makes this method a good option for boron-containing drugs with potential for use in boron neutron capture therapy (BNCT).
Topics & Concepts
BoraneAdductRegioselectivityChemistryPyridineLewis acids and basesFrustrated Lewis pairBase (topology)Substitution (logic)Medicinal chemistrySubstitution reactionStereochemistryOrganic chemistryCatalysisComputer scienceMathematicsProgramming languageMathematical analysisOrganoboron and organosilicon chemistryBoron Compounds in ChemistryCoordination Chemistry and Organometallics