Intranasal delivery of engineered extracellular vesicles loaded with miR-206-3p antagomir ameliorates Alzheimer's disease phenotypes
Dong Peng, Tingting Liu, Huahui Lu, Lei Zhang, Hongxia Chen, Yadong Huang, Bo Hu, Qihao Zhang
Abstract
Our findings highlight the intranasal administration of MSC-EVs-anta as a promising strategy for the treatment of AD.
Topics & Concepts
Extracellular vesiclesNasal administrationPhenotypeDiseaseExtracellularMicrovesiclesAntagomirAlzheimer's diseaseMedicineExtracellular vesicleVesicleCell biologyCancer researchChemistryPathologymicroRNABiologyPharmacologyGeneMembraneBiochemistryExtracellular vesicles in disease