Repurposing <sup>18</sup>F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy
Gorka Ruíz de Garibay, Elvira García de Jalón, Endre Stigen, Kjetil B. Lund, Mihaela Popa, Ben Davidson, Mireia Mayoral Safont, Cecilie Brekke Rygh, Heidi Espedal, Torill M. Barrett, Bengt Erik Haug, Emmet McCormack
Abstract
F-FMISO as a readily implementable PET imaging probe to be employed as companion diagnostic test for NTR-based GDEPT systems.
Topics & Concepts
ProdrugBiodistributionIn vivoBioluminescence imagingNitroreductasePositron emission tomographyEx vivoCancer researchChemistryMedicineTransduction (biophysics)PharmacologyNuclear medicineTransfectionLuciferaseBiologyBiochemistryGeneBiotechnologyCancer Research and TreatmentsVirus-based gene therapy researchBiochemical and Molecular Research