Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors
Tobias Bexte, Lacramioara Botezatu, Csaba Miskey, F Gierschek, Alina Moter, Philipp Wendel, Lisa Marie Reindl, Julia Campe, Jose Francisco Villena-Ossa, Veronika Gebel, K. S. Stein, Toni Cathomen, Anjali Cremer, Winfried S. Wels, Michael Hudecek, Zoltán Ivics, Evelyn Ullrich
Topics & Concepts
Chimeric antigen receptorTransposaseNK-92Adoptive cell transferBiologyCancer cellCytotoxic T cellLeukemiaCancer researchViral vectorTransfectionInterleukin 21ImmunotherapyImmunologyCancerIn vitroImmune systemTransposable elementCell cultureRecombinant DNAGeneGeneticsGenomeCAR-T cell therapy researchImmune Cell Function and InteractionVirus-based gene therapy research