Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies
David W. Scott, Kathleen P. Pratt
Abstract
Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it.
Topics & Concepts
ImmunogenicityMedicineAntibody responseImmunologyAntibodyFunction (biology)BiologyCell biologyPlatelet Disorders and TreatmentsHemophilia Treatment and ResearchHemostasis and retained surgical items