Sustainable Four-Component Annulation for the Synthesis of 2,3,4,6-Tetraarylpyridines
Yuxin Ding, Renchao Ma, Xu‐Qiong Xiao, Lei Wang, Zhiming Wang, Yongmin Ma
Abstract
A one-pot, four-component annulation of 2,3,4,6-tetraarylpyridines from aromatic aldehydes, methyl ketones, diaryl ethanones, and ammonium acetate is described. The reaction features high functional group compatibility in air under solvent-free conditions without any additive and only water as the nontoxic byproduct, providing a strategy for the facile, economical, and eco-friendly construction of multiaryl-substituted pyridines from simple and readily available reactants.
Topics & Concepts
ChemistryAnnulationAmmonium acetateEnvironmentally friendlyCompatibility (geochemistry)Organic chemistryComponent (thermodynamics)Reaction conditionsSolventGreen chemistryFunctional groupCombinatorial chemistryCatalysisReaction mechanismChemical engineeringEngineeringHigh-performance liquid chromatographyPolymerBiologyEcologyThermodynamicsPhysicsMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of Tetrazole Derivatives