Osteoporotic fractures: an unrecognized adverse event of immune checkpoint inhibitors?
Manar Elsayed, Carrie Ye
Abstract
The widespread use of immune checkpoint inhibitors (ICIs) in clinical practice has broadened our understanding of their immune-related adverse events (irAEs). IrAEs, including musculoskeletal adverse events, remain a significant concern. While ICI-associated arthritis is a well-documented musculoskeletal side effect of ICI therapy, the direct effects of ICIs on bone in patients with cancer are poorly understood. There is emerging evidence to support the hypothesis that ICIs adversely impact bone turnover and can lead to osteoporosis and fragility fractures, which are not currently recognized as irAEs.
Topics & Concepts
Adverse effectMedicineOsteoporosisImmune systemBone remodelingIntensive care medicineBioinformaticsInternal medicineOncologyImmunologyBiologyCancer Immunotherapy and BiomarkersColorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways