Development and validation of a novel LC-MS/MS method for simultaneous quantitative determination of tyrosine kinase inhibitors in human plasma
Yutao Lou, Hui Qin, Qing Hu, Yitao Chai, Hongying Zhou, Mengting Chen, Qiyue Wang, Ping Huang, Jinping Gu, Yiwen Zhang
Topics & Concepts
ChemistryChromatographyProtein precipitationBioanalysisCeritinibAnalyteFormic acidCrizotinibSelected reaction monitoringElectrospray ionizationTherapeutic drug monitoringDetection limitExtraction (chemistry)Mass spectrometrySample preparationTandem mass spectrometryLiquid chromatography–mass spectrometryPharmacokineticsInternal medicineMalignant pleural effusionSurgeryPleural effusionMedicineChronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia ResearchQuinazolinone synthesis and applications