Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation
Bryan J. Fraser, Serap Beldar, Almagul Seitova, Ashley Hutchinson, Dhiraj Mannar, Yanjun Li, Daniel Kwon, Ruiyan Tan, Ryan P. Wilson, Karoline Leopold, Sriram Subramaniam, Levon Halabelian, C.H. Arrowsmith, François Bénard
Topics & Concepts
TMPRSS2ProteaseSerine proteaseProteasesTransmembrane proteinBiologyProtease inhibitor (pharmacology)Recombinant DNAFusion proteinVirusChemistryVirologyBiochemistryEnzymeCoronavirus disease 2019 (COVID-19)GeneMedicineReceptorViral loadInfectious disease (medical specialty)Antiretroviral therapyDiseasePathologySARS-CoV-2 and COVID-19 Researchinterferon and immune responsesvaccines and immunoinformatics approaches