Reciprocal change in Glucose metabolism of Cancer and Immune Cells mediated by different Glucose Transporters predicts Immunotherapy response
Kwon Joong Na, Hongyoon Choi, Ho Rim Oh, Yoon Ho Kim, Sae Bom Lee, Yoo Jin Jung, Jaemoon Koh, Samina Park, Hyun Joo Lee, Yoon Kyung Jeon, Doo Hyun Chung, Jin Chul Paeng, In Kyu Park, Chang Hyun Kang, Gi Jeong Cheon, Keon Wook Kang, Dong Soo Lee, Young Tae Kim
Abstract
Competitive uptake of glucose by cancer and immune cells in TME could be mediated by differential GLUT expression in these cells.
Topics & Concepts
Immune systemImmunotherapyTransporterCancer immunotherapyCancerMetabolismGlucose transporterCarbohydrate metabolismCancer researchCancer cellBiologyChemistryMedicineImmunologyBiochemistryInternal medicineEndocrinologyGeneInsulinCancer Immunotherapy and BiomarkersImmune cells in cancerPancreatic and Hepatic Oncology Research