LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson’s disease progression
Qian Zhou, Mingming Zhang, Min Liu, Zhigang Tan, Qilin Qin, Yugang Jiang
Abstract
experiments confirmed the neuroprotective effects of shXIST and miR-199a-3p against MPTP-induced brain injuries, and the Parkinson's disease behavioural symptoms were effectively alleviated upon shXIST or miR-199a-3p treatment. In summary, the results of the present study showed that lncRNA XIST sponges miR-199a-3p to modulate Sp1 expression and further accelerates Parkinson's disease progression by targeting LRRK2.
Topics & Concepts
XISTLRRK2Parkinson's diseaseDiseaseSignal pathwaySignal transductionNeuroscienceBiologyCell biologyMedicineCancer researchGeneticsPathologyGeneX chromosomeX-inactivationRNA regulation and diseaseCancer-related molecular mechanisms researchParkinson's Disease Mechanisms and Treatments