Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells
Madhura Deshpande, Theodore Paniza, Nahed Jalloul, Gouri J. Nanjangud, Jerzy M. Twarowski, Amnon Koren, Nikica Zaninović, Qiansheng Zhan, Kalyani Chadalavada, Anna Malkova, Hossein Khiabanian, Advaitha Madireddy, Zev Rosenwaks, Jeannine Gerhardt
Topics & Concepts
BiologyHaploinsufficiencyLoss of heterozygosityMutagenesisGeneticsCarcinogenesisMutationDNA repairGeneGenome instabilityDNA replicationGermlineMolecular biologyAlleleDNA damageDNAPhenotypeCRISPR and Genetic EngineeringDNA Repair MechanismsBRCA gene mutations in cancer