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Absorption, distribution, metabolism, excretion (ADME), drug-drug interaction potential and prediction of human pharmacokinetics of SUVN-G3031, a novel histamine 3 receptor (H3R) inverse agonist in clinical development for the treatment of narcolepsy

Ramakrishna Nirogi, Gopinadh Bhyrapuneni, Nageswara Rao Muddana, Arunkumar Manoharan, Anil Shinde, Abdul Rasheed Mohammed, Nagasurya Prakash Padala, Devender Reddy Ajjala, Ramkumar Subramanian, Veera Raghava Chowdary Palacharla

2020European Journal of Pharmaceutical Sciences11 citationsDOI

Topics & Concepts

MetaboliteADMEPharmacokineticsPharmacologyChemistryInverse agonistDrug metabolismCYP3A4AgonistMetabolismCytochrome P450ReceptorBiochemistryBiologyPharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsReceptor Mechanisms and Signaling
Absorption, distribution, metabolism, excretion (ADME), drug-drug interaction potential and prediction of human pharmacokinetics of SUVN-G3031, a novel histamine 3 receptor (H3R) inverse agonist in clinical development for the treatment of narcolepsy | Litcius