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Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis

Samantha M. Golomb, Ian H. Guldner, Anqi Zhao, Qingfei Wang, Bhavana Palakurthi, Emilija Aleksandrovic, Jacqueline Lopez, Shaun W. Lee, Kai Yang, Siyuan Zhang

2020Cell Reports71 citationsDOIOpen Access PDF

Abstract

) signature, which is reduced through antibiotics-induced gut dysbiosis. Systemic changes due to aging and gut dysbiosis increase propensity for neuroinflammation, providing insights into gut dysbiosis in age-related neurological diseases.

Topics & Concepts

DysbiosisImmune systemBiologyPlasticityGut floraNeuroscienceGut–brain axisImmunologyThermodynamicsPhysicsNeuroinflammation and Neurodegeneration MechanismsGut microbiota and healthTryptophan and brain disorders