Stabilization of Murine Norovirus by Bacteria
Melissa R. Budicini, Julie K. Pfeiffer
Abstract
Enteric viruses are exposed to a wide variety of bacteria in the intestine, but the effects of bacteria on viral particles are incompletely understood. We found that murine norovirus (MNV) virion stability is enhanced in the presence of several Gram-positive bacterial strains. Virion-stabilizing activity was also present in bacterial culture medium, and activity was retained upon heat or protease treatment. These results suggest that certain bacteria and bacterial products may promote MNV stability in the environment, which could influence viral transmission.
Topics & Concepts
NorovirusMurine norovirusBacteriaMicrobiologyBiologyVirologyEnteric bacteriaGram-negative bacteriaVirusEscherichia coliGeneticsGeneViral gastroenteritis research and epidemiologyAnimal Virus Infections StudiesVirus-based gene therapy research