Pleiotropic effects of PCSK9-inhibition on hemostasis: Anti-PCSK9 reduce FVIII levels by enhancing LRP1 expression
Francesco Paciullo, Eleonora Petito, Emanuela Falcinelli, Paolo Gresele, Stefania Momi
Topics & Concepts
PCSK9LDL receptorKexinChemistryProprotein convertaseHepatocyteReductaseHMG-CoA reductaseLRP1EndocytosisIntracellularCholesterolLipoproteinInternal medicineReceptorEndocrinologyBiochemistryEnzymeBiologyMedicineIn vitroLipoproteins and Cardiovascular HealthProtease and Inhibitor MechanismsBlood Coagulation and Thrombosis Mechanisms