Amyloid-β regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes
Mahua Maulik, Lakshmy Vasan, Abhishek Bose, Saikat Dutta Chowdhury, Neelanjana Sengupta, Jayasri Das Sarma
Abstract
molecular docking suggests that Aβ can bind favorably to Cx43. Our study thus provides novel insights into the cellular mechanisms by which Aβ modulates Cx43 function in astrocytes, the basic understanding of which is vital for the development of alternative therapeutic strategy targeting connexin channels in AD.
Topics & Concepts
Gap junctionConnexinCell biologyAstrocyteIntracellularConnexonInternalizationEndoplasmic reticulumPannexinBiologyCell junctionAstrogliosisTransport proteinEndocytosisChemistryCellNeuroscienceBiochemistryCentral nervous systemConnexins and lens biologyNicotinic Acetylcholine Receptors StudyYersinia bacterium, plague, ectoparasites research