Volcano-Shaped Scanning Probe Microscopy Probe for Combined Force-Electrogram Recordings from Excitable Cells
B. X. E. Desbiolles, Mélanie T. M. Hannebelle, Etienne de Coulon, Arnaud Bertsch, Stephan Rohr, Georg E. Fantner, Philippe Renaud
Abstract
were achieved using these nanovolcano probes. Furthermore, proof of concept experiments demonstrated that extracellular field potentials (electrogram) together with contraction displacement curves could simultaneously be recorded. These features render the nanovolcano probe especially suited for mechanobiological studies aiming at linking mechanical stimuli to electrophysiological responses of single cells.
Topics & Concepts
MicroelectrodeMechanobiologyMicroscopyElectrophysiologyMultielectrode arrayScanning probe microscopyScanning ion-conductance microscopyAtomic force microscopyMaterials scienceBiomedical engineeringNanotechnologyCantileverChemistryOpticsAnatomyNeuroscienceElectrodeScanning confocal electron microscopyPhysicsPhysical chemistryComposite materialMedicineBiologyForce Microscopy Techniques and ApplicationsNeuroscience and Neural EngineeringMechanical and Optical Resonators