Neuronal STAT3/HIF-1α/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A
Weili Jin, Jixing Zhao, Eryan Yang, Yunfei Wang, Qixue Wang, Ye Wu, Fei Tong, Yanli Tan, Junhu Zhou, Chunsheng Kang
Abstract
Our results thus identify that the STAT3/HIF-1α/PTRF-axis in neurons, aggravating cerebral I/R injury by regulating the activity and stability of PLA2G4A, might be a novel therapeutic target for ischemic stroke.
Topics & Concepts
Cell biologyBiologySmall hairpin RNAChemistryMolecular biologyRNABiochemistryGeneCancer-related molecular mechanisms researchRNA modifications and cancerCancer, Hypoxia, and Metabolism