Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer
Hong-Yuan Tsai, Mary P. Bronner, Jordon K. March, John F. Valentine, Noah F. Shroyer, Lisa A. Lai, Teresa A. Brentnall, Sheng Pan, Ru Chen
Topics & Concepts
Oxidative stressChemistryGCLCReactive oxygen speciesDownregulation and upregulationKEAP1Programmed cell deathApoptosisGCLMCancer researchUnfolded protein responseCell biologyBiochemistryBiologyTranscription factorGeneGenomics, phytochemicals, and oxidative stressHeat shock proteins researchCoenzyme Q10 studies and effects