NCF4 dependent intracellular reactive oxygen species regulate plasma cell formation
Chang He, Huqiao Luo, Ana Coelho, Meng Liu, Qijing Li, Jing Xu, Alexander Krämer, Stephen Malin, Zuyi Yuan, Rikard Holmdahl
Abstract
mutated animals without significant effects on antigen presentation, autoreactive T cell activation and germinal center formation. Instead, plasma cell formation was enhanced and had altered CXCR3/CXCR4 expression. This B cell intrinsic effect was further confirmed with chimeric B cell transfer experiments and in vitro LPS or CD40L with anti-IgM stimulation. We conclude that NCF4 regulates the terminal differentiation of B cells to plasma cells through intracellular ROS.
Topics & Concepts
IntracellularNADPH oxidaseCell biologyReactive oxygen speciesChemistryGerminal centerT cellExtracellularPlasma cellB cellBiologyMolecular biologyAntibodyImmunologyImmune systemNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune Response and InflammationT-cell and B-cell Immunology