Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne J. Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny, Fabio Broccatelli
Topics & Concepts
ExtrapolationIn vivoPharmacokineticsScalingChemistryMathematicsPharmacologyStatisticsMedicineBiologyBiotechnologyGeometryComputational Drug Discovery MethodsPharmacogenetics and Drug MetabolismAnalytical Chemistry and Chromatography