Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury
Jesús Amo‐Aparicio, Joana Garcia-Garcia, Isaac Francos-Quijorna, Andrea Urpi, Anna Esteve‐Codina, Marta Gut, Albert Quintana, Rubén López‐Vales
Abstract
These results reveal that the metabolic fitness of microglia and macrophages after SCI contributes to secondary damage and that strategies aimed at boosting oxidative phosphorylation might be a novel approach to minimize the deleterious actions of microglia and macrophages in neurotrauma.
Topics & Concepts
MicrogliaInflammationMacrophageInterleukinBiologyImmunologyProinflammatory cytokineCell biologyPhenotypeCytokineIn vitroBiochemistryGeneNeuroinflammation and Neurodegeneration MechanismsImmune Response and InflammationImmune cells in cancer