Copper Phosphide Nanoparticles Used for Combined Photothermal and Photodynamic Tumor Therapy
Qi Fan, Yun Chang, Runxiao Zheng, Xiaqing Wu, Yunyun Wu, Bing Li, Tingting Sun, Pingcun Wang, Hao Zhang, Haiyuan Zhang
Abstract
Copper-based nanomaterials are widely used in near-infrared (NIR) light-mediated deep tumor treatment because of their abundant photothermal and photodynamic properties. However, copper phosphide (Cu3P) nanoparticles (NPs) are rarely investigated. Herein, Cu3P NPs were prepared to strengthen their local surface plasmon resonance absorption in the NIR region, exhibiting promising photothermal and photodynamic properties. After surface modification by polyethylene glycol, the formed pCu3P NPs showed negligible influence on the viability of 4T1 cells, presenting remarkable biocompatibility. However, with 808 nm irradiation, pCu3P NPs could induce HSP70 and HO-1 protein expression and enhance intracellular reactive oxygen species levels, leading to dramatic cell death. In 4T1 tumor-bearing mice, an intravenous injection of biocompatible pCu3P NP could lead to remarkable aggregation in the tumor region and significantly inhibit tumor growth under 808 nm laser irradiation, presenting great potential for tumor therapy.