Targeting mitochondrial proteases for therapy of acute myeloid leukaemia
Xinrong Xiang, Rui Bao, Yu Wu, Youfu Luo
Abstract
Targeting cancer metabolism has emerged as an attractive approach to improve therapeutic regimens in acute myeloid leukaemia (AML). Mitochondrial proteases are closely related to cancer metabolism, but their biological functions have not been well characterized in AML. According to different categories, we comprehensively review the role of mitochondrial proteases in AML. This review highlights some 'powerful' mitochondrial protease targets, including their biological function, chemical modulators, and applicative prospect in AML.
Topics & Concepts
ProteasesCancerMyeloid leukaemiaMitochondrionFunction (biology)BiologyProteaseCancer researchMyeloidBioinformaticsMedicineComputational biologyEnzymeCell biologyBiochemistryGeneticsAcute Myeloid Leukemia ResearchMitochondrial Function and PathologyHistone Deacetylase Inhibitors Research