Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway
Xian-Qiang Ni, Ya-Rong Zhang, Lixin Jia, Weiwei Lu, Qing Zhu, Jin-Ling Ren, Yao Chen, Linshuang Zhang, Xin Liu, Yan-Rong Yu, Mo-Zhi Jia, Zhongping Ning, Jie Du, Chaoshu Tang, Yongfen Qi
Abstract
(IMD receptors blocking peptide) and the phosphatidylinositol 3-kinase/protein kinase b (PI3K/Akt) inhibitor LY294002 reversed ADAM10 level. In conclusion, exogenous and endogenous IMD could inhibit the development of AAA by inhibiting Notch1 signaling-mediated inflammation via reducing ADAM10 through IMD receptor and PI3K/Akt pathway.
Topics & Concepts
InflammationPI3K/AKT/mTOR pathwayAbdominal aortic aneurysmProtein kinase BMedicineSignal transductionAortic aneurysmCancer researchPharmacologyInternal medicineCell biologyAneurysmBiologySurgeryAortaMacrophage Migration Inhibitory FactorInflammation biomarkers and pathwaysAortic aneurysm repair treatments