Apilimod alters TGFβ signaling pathway and prevents cardiac fibrotic remodeling
Mathieu Cinato, Laurie Guitou, Amira Saidi, Andreï Timotin, Erwan Sperazza, Thibaut Duparc, Sergey N. Zolov, Sai Srinivas Panapakkam Giridharan, Lois S. Weisman, Laurent O. Martinez, Jérôme Roncalli, Oksana Kunduzova, Hélène Tronchère, Frédéric Boal
Abstract
Altogether, our findings propose a novel function for PIKfyve in the control of myocardial fibrotic remodeling and the TGFβ signaling pathway, therefore opening the way to new therapeutic perspectives to prevent adverse fibrotic remodeling using Apilimod treatment.
Topics & Concepts
Signal transductionFibrosisTransforming growth factorCell biologyCancer researchPathologicalVentricular remodelingHeart failureMedicineBiologyPathologyInternal medicineCardiac Fibrosis and RemodelingPeptidase Inhibition and AnalysisInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis