Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C–H Activation
Yusong Ye, Madeline Berry, William J. Bock, Kunpeng Cheng, Sajiv K. Nair, Christiana S. Park, Ryan L. Patman, Sylvie K. Sakata, Michelle Tran‐Dubé, Joyann S. Donaldson, Guanyu Yang, Guansai Liu
Abstract
Isoquinolone is one of the most common heterocyclic core structures in countless natural products and many bioactive compounds. Here, a highly efficient approach to synthesize isoquinolone scaffolds on DNA via rhodium(III)-catalyzed C-H activation has been described. This chemistry transformation is robust and has shown good compatibility with DNA, which is suitable for DNA-encoded library synthesis.
Topics & Concepts
ChemistryRhodiumCatalysisDNACombinatorial chemistryCompatibility (geochemistry)StereochemistryOrganic chemistryBiochemistryChemical engineeringEngineeringCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms