New 30-substituted derivatives of pentacyclic triterpenes: preparation, biological activity, and molecular docking study
Elwira Chrobak, Ewa Bębenek, Krzysztof Marciniec, Monika Kadela-Tomanek, Szymon Siudak, Małgorzata Latocha, Stanisław Boryczka
Topics & Concepts
ChemistryPolar surface areaLipophilicityHydrogen bondTriterpeneStereochemistryDocking (animal)ADMECytotoxicityAKT1TerpeneMolecular modelHydrophobic effectIn vitroCombinatorial chemistryOrganic chemistryMoleculeBiochemistryPhosphorylationProtein kinase BNursingAlternative medicineMedicinePathologyNatural product bioactivities and synthesisPlant biochemistry and biosynthesisPhytochemical compounds biological activities