Alkenes as hydrogen trappers to control the regio-selective ruthenium(<scp>ii</scp>) catalyzed <i>ortho</i> C–H silylation of amides and anilides
Qiao Lin, Zirui Lin, Mingxing Pan, Qiaojin Zheng, Hui Li, Xiuwen Chen, Christophe Darcel, Pierre H. Dixneuf, Bin Li
Abstract
A convenient and practical pathway to versatile silylated amides and anilides is described <italic>via</italic> efficient and selective ruthenium(<sc>ii</sc>) catalyzed <italic>ortho</italic> C–H silylation with different alkenes as the hydrogen acceptors.
Topics & Concepts
RutheniumChemistrySilylationCatalysisMedicinal chemistryHydrogenOrganic chemistryStereochemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions