Formation of highly stable multinuclear Ag<sub>n</sub>S<sub>n</sub>clusters in zinc fingers disrupts their structure and function
Katarzyna Kluska, Manuel David Peris‐Díaz, Dawid Płonka, Alexander Moysa, Michał Dadlez, Aurélien Deniaud, Wojciech Bal, Artur Krężel
Abstract
structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Ag(i)-induced conformational changes of ZFs can, as a consequence, affect transcriptional regulation and other cellular processes.
Topics & Concepts
ZincChemistryCluster (spacecraft)CrystallographyMoleculeFunction (biology)BiophysicsBiologyCell biologyProgramming languageOrganic chemistryComputer scienceTrace Elements in HealthNanocluster Synthesis and ApplicationsMetal complexes synthesis and properties