GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress
Yu Kato, Kazuhiro Kunimasa, Mizuki Takahashi, Ayaka Harada, Ikuko Nagasawa, Masanori Osawa, Yoshikazu Sugimoto, Akihiro Tomida
Topics & Concepts
Integrated stress responseATF4KinaseeIF2Cancer cellSignal transductionPhosphorylationBiologyAmino acidCell biologyTranscription factorBiochemistryUnfolded protein responseChemistryCancerMessenger RNATranslation (biology)ApoptosisGeneticsGeneEndoplasmic Reticulum Stress and DiseaseGenomics, phytochemicals, and oxidative stressRNA regulation and disease