LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network
Yin Zhang, Yongxin Huang, Dan-Lan Wang, Bing Yang, Haiyan Yan, Lehang Lin, Yun Li, Jie Chen, Li‐Min Xie, Yongsheng Huang, Jian‐You Liao, Kaishun Hu, Jiehua He, Phei Er Saw, Xiaoding Xu, Dong Yin
Abstract
Our study demonstrated that lncRNA DSCAM-AS1 was transcriptionally activated by super-enhancers driven by FOXA1 and exhibited lineage-specific expression pattern. DSCAM-AS1 can promote cancer progression by interacting with YBX1 and regulating expression of FOXA1 and ERα.
Topics & Concepts
Transcription factorCancer researchLoop (graph theory)Transcription (linguistics)Positive feedbackFOXA1Cell biologyChemistryBiologyMedicineGeneticsGeneMathematicsCombinatoricsEngineeringLinguisticsElectrical engineeringPhilosophyCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing