CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway
Rui Sun, Xucan Tu, Shixin Chan, Xu Wang, Yizhong Ji, Zhenglin Wang, Zhen Yu, Xiaomin Zuo, Qing Zhang, Jiajie Chen, Qijun Han, Ming Wang, Zhao Hu, Huabing Zhang, Wei Chen
Abstract
. Furthermore, downregulation of CBX2 promotes CRC cell apoptosis and hinders the cell cycle. Mechanistically, our data demonstrated that deletion of CBX2 inhibited the MAPK signaling pathway by regulating the protein levels of Mettl3. In conclusion, our study demonstrated that CBX2 is a vital tumor suppressor in CRC and could be a promising anti-cancer therapeutic target.
Topics & Concepts
Colorectal cancerCancer researchMAPK/ERK pathwayDownregulation and upregulationMetastasisCell growthApoptosisCancerSuppressorp38 mitogen-activated protein kinasesCell cycleMedicineCell biologySignal transductionBiologyInternal medicineGeneticsGeneEpigenetics and DNA MethylationRNA modifications and cancerCancer-related gene regulation