Pan-cancer noncoding genomic analysis identifies functional CDC20 promoter mutation hotspots
Zaoke He, Tao Wu, Shixiang Wang, Jing Zhang, Xiaoqin Sun, Ziyu Tao, Xiangyu Zhao, Huimin Li, Kai Wu, Xuesong Liu
Abstract
gene deregulation in human cancers but also finds functional noncoding genetic alterations, with implications for the further development of function-based noncoding driver discovery pipelines.
Topics & Concepts
BiologyGeneticsGeneRepressorTranscription factorFunctional genomicsPromoterDNA binding siteGenomeComputational biologyGenomicsGene expressionCancer Genomics and DiagnosticsGenomics and Chromatin DynamicsRNA and protein synthesis mechanisms